SAFETY, TOLERABILITY, AND DOSE-LIMITING TOXICITY OF LACOSAMIDE IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS: PROTOCOL FOR A PHASE 1 CLINICAL TRIAL TO DETERMINE SAFETY AND IDENTIFY SIDE EFFECTS

BackgroundChronic abdominal Winter Sports - Gear pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia is a phenomenon r

Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally.Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to

Digital mental health interventions, such as those provided by smartphone applications (apps), show promise as cost-effective approaches to increasing access to evidence-based psychosocial interventions for psychosis.Although it is well known that limited financial resources can reduce the benefits of digital approaches to mental healthcare, the ex

Since 1871 when the Colombo Medical College was instituted, the education of undergraduates and postgraduates in medicine, over the succeeding decades, had the prime aim of producing doctors who could deliver health care.This Warewashing:Cleaning was the continuation of British colonial policy.The establishment of the University of Ceylon in 1942 c